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脑脊液检查结果正常的细菌性脑膜炎。病例报告及文献复习。

Bacterial meningitis with normal cerebrospinal fluid findings. Report of a case and review of the literature.

作者信息

Araj G F, Hamati A I, Sinno D D, Issa A M, Musallam S S

机构信息

Department of Laboratory Medicine, American University of Beirut Medical Center, Lebanon.

出版信息

J Med Liban. 1993;41(2):86-9.

PMID:8057349
Abstract

Bacterial meningitis presenting with normal initial CSF findings is rare and could be confusing to the physicians. Such an entity was observed in this first case report from Lebanon on an 8-month-old female febrile infant whose initial CSF studies were normal despite the culture yielding Streptococcus pneumoniae. Thus, this case emphasizes the need that physicians should start antimicrobial therapy, pending culture results, whenever bacterial meningitis is clinically suspected, even if initial CSF investigation of cellular, protein, sugar and gram-strain results do not reveal abnormal findings. In addition, repeat lumbar puncture should be considered in all febrile patients having clinical features suggestive of this diagnosis.

摘要

初始脑脊液检查结果正常的细菌性脑膜炎较为罕见,可能会让医生感到困惑。在黎巴嫩的这篇首例病例报告中就观察到了这样一个病例,一名8个月大发热女婴,尽管脑脊液培养结果显示为肺炎链球菌,但最初的脑脊液检查却是正常的。因此,该病例强调,只要临床怀疑为细菌性脑膜炎,即使脑脊液细胞、蛋白质、糖和革兰氏染色的初始检查结果未显示异常,医生也应在等待培养结果期间开始抗菌治疗。此外,对于所有具有提示该诊断临床特征的发热患者,都应考虑重复腰椎穿刺。

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