Jannet D, Carbonne B, Sebban E, Milliez J
Department of Obstetrics and Gynecology, Hôpital Saint-Antoine, Paris, France.
Obstet Gynecol. 1994 Sep;84(3):354-9.
To compare the effects of treatment with nicardipine and metoprolol in patients with hypertension during pregnancy.
One hundred pregnant patients with mild or moderate hypertension followed at the Centre Hospitalier Intercommunal de Créteil (France) were randomly allocated to treatment with either nicardipine or metoprolol. Changes in maternal blood pressure (BP), laboratory indices, umbilical Doppler velocimetry, and neonatal outcome were compared by means of Student t test, chi 2 test, and analysis of variance.
Nicardipine decreased maternal systolic and diastolic BP more than metoprolol (P < .001). Umbilical artery resistance was lower in nicardipine-treated patients (P < .001). Plasma uric acid and creatinine concentrations were increased less markedly in the nicardipine group (P < .05 and P < .01, respectively). The incidence of cesarean delivery for fetal distress was lower in the nicardipine group (P < .01). There was a trend toward higher birth weights in the nicardipine group but no significant difference in neonatal outcome.
Nicardipine is more effective than metoprolol in decreasing maternal BP; neonatal outcome is not significantly different.
比较尼卡地平和美托洛尔对妊娠期高血压患者的治疗效果。
法国克雷泰伊市立中心医院随访的100例轻度或中度高血压孕妇被随机分配接受尼卡地平或美托洛尔治疗。通过学生t检验、卡方检验和方差分析比较孕妇血压（BP）、实验室指标、脐动脉多普勒测速及新生儿结局的变化。
尼卡地平降低孕妇收缩压和舒张压的效果优于美托洛尔（P <.001）。尼卡地平治疗组的脐动脉阻力较低（P <.001）。尼卡地平组血浆尿酸和肌酐浓度升高不明显（分别为P <.05和P <.01）。尼卡地平组因胎儿窘迫行剖宫产的发生率较低（P <.01）。尼卡地平组出生体重有升高趋势，但新生儿结局无显著差异。
尼卡地平在降低孕妇血压方面比美托洛尔更有效；新生儿结局无显著差异。
