Bán A
Orv Hetil. 1994 Jul 10;135(28):1527-30.
The antitumor effect of different retinoids focused attention in the treatment of malignant disorders on different pathways. The therapeutic effect was proved in acute promyelocytic leukaemia, but was limited in juvenile form of chronic myeloid leukaemia and in acute myelomonocytic and monoblastic leukaemia. Combined with different leukostatics, long remission could be achieved. The most important therapeutic pathway is direct growth inhibition with and without cell differentiation. Clinically, retinoids are effective in tumours, like: cutan T-cell lymphoma, mycosis fungoides, Sézary syndrome, oral leukoplakia (prevention of head and neck cancer metastases), variant form of small lung cell carcinoma, oestrogen dependent breast-carcinoma and cervix-carcinoma. The most serious complication of the retinoids' administration is the retinoic acid syndrome which is followed sometimes with thromboembolic events. Retinoids are teratogenic and hepatotoxic.
不同类视黄醇的抗肿瘤作用在恶性疾病治疗中聚焦于不同途径。在急性早幼粒细胞白血病中已证实其治疗效果，但在青少年型慢性髓细胞白血病以及急性粒单核细胞白血病和单核细胞白血病中效果有限。与不同的白细胞抑制剂联合使用，可实现长期缓解。最重要的治疗途径是直接抑制生长，无论有无细胞分化。在临床上，类视黄醇对以下肿瘤有效：皮肤T细胞淋巴瘤、蕈样肉芽肿、塞扎里综合征、口腔白斑（预防头颈癌转移）、小细胞肺癌变异型、雌激素依赖性乳腺癌和宫颈癌。类视黄醇给药最严重的并发症是维甲酸综合征，有时会伴有血栓栓塞事件。类视黄醇具有致畸性和肝毒性。
