Jourdan C, Convert J, Rousselle C, Wasylkiewicz J, Mircevski V, Mottolese C, Lapras C
Service d'anesthésie-réanimation, hôpital neurologique et neurochirurgical P-Wertheimer, Lyon, France.
Pediatrie. 1993;48(11):805-12.
Acute neurogenic pulmonary edema (NPE) can dramatically complicate a serious brain injury. From bibliographic data and four personal cases documented by and haemodynamical study, the authors analyse the pathophysiological mechanisms and the haemodynamical changes resulting from massive sympathic outflow, the main mechanism of NPE being haemodynamical rather than lesional. This rare complication needs to be recognized in order to undergo an intensive care treatment generally leading to a favourable evolution. This treatment lies on circulatory and ventilatory supports with positive and expiratory pressure in order to maintain an optimal oxygenation and an optimal cerebral perfusion pressure. With this treatment the outcome of NPE is usually favourable with complete recovery within 2 to 5 days.
急性神经源性肺水肿(NPE)可使严重脑损伤显著复杂化。根据文献数据以及作者记录的4例个人病例并进行血流动力学研究,分析了大量交感神经冲动释放所导致的病理生理机制和血流动力学变化,NPE的主要机制是血流动力学方面的而非损伤性的。需要认识到这种罕见的并发症,以便进行重症监护治疗,通常会带来良好的转归。这种治疗基于循环和通气支持以及呼气末正压,以维持最佳氧合和最佳脑灌注压。采用这种治疗方法,NPE的预后通常良好,2至5天内可完全恢复。