γ-氨基丁酸介导可乐定对小鼠戊四氮诱发癫痫的抗惊厥作用
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
作者信息
Amabeoku G, Chikuni O, Bwakura E
机构信息
Department of Clinical Pharmacology, Medical School, University of Zimbabwe, Avondale, Harare.
出版信息
Pharmacol Res. 1994 Apr;29(3):273-80. doi: 10.1016/1043-6618(94)80050-2.
The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice. Muscimol, AOAA, DABA, phenobarbitone and diazepam significantly protected mice against pentylenetetrazol-induced seizures and also significantly potentiated the protective effect of clonidine against the seizures. Bicuculline and picrotoxin significantly potentiated seizures induced by pentylenetetrazol and significantly attenuated both the protective effects of muscimol and clonidine against the seizures. These data suggest that activation of gamma-aminobutyric acid systems may underlie the protective effect of clonidine against seizures induced by pentylenetetrazol in mice.
在小鼠中研究了蝇蕈醇、氨氧基乙酸（AOAA）、二氨基-N-丁酸（DABA）、荷包牡丹碱、印防己毒素、地西泮和苯巴比妥对可乐定抗戊四氮诱发惊厥保护作用的影响。蝇蕈醇、AOAA、DABA、苯巴比妥和地西泮显著保护小鼠免受戊四氮诱发的惊厥，并且还显著增强了可乐定对惊厥的保护作用。荷包牡丹碱和印防己毒素显著增强戊四氮诱发的惊厥，并显著减弱蝇蕈醇和可乐定对惊厥的保护作用。这些数据表明，γ-氨基丁酸系统的激活可能是可乐定对小鼠戊四氮诱发惊厥保护作用的基础。
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