Trofimov V M, Mazurov V I, Arkhipov V F, Klimko N N
Probl Endokrinol (Mosk). 1993 Jan-Feb;39(1):30-3.
Measurements of the daily fluctuations in the sugar blood levels, fasting test, the double glucose tolerance test, and measurements of the blood insulin and C peptide levels were carried out in 13 patients with organic hyperinsulinism prior to insulinoma removal and in the immediate and late periods after it. The double glucose tolerance test was for the first time used to study carbohydrate metabolism in patients with organic hyperinsulinism. The curve of this test in insulinoma patients was found to resemble that in health though with lower levels and a more abrupt lowering of its end section. This feature may be used to define the origin of hyperinsulinism. No correlation between the blood glucose, insulin, and C peptide levels was detectable before surgery in this patient population. After surgery the imbalance in these three parameters relationships is eliminated. Carbohydrate metabolism parameters normalized after the operation; the lowest blood sugar level was increased twofold in the fasting test. Transitory hyperglycemia persisted for two weeks after elimination of hyperinsulinism. Daily fluctuations in the blood sugar levels normalize during the third week after surgery.
对13例器质性高胰岛素血症患者在切除胰岛素瘤之前、切除术后即刻及晚期进行了血糖水平的每日波动测量、空腹试验、双重葡萄糖耐量试验以及血胰岛素和C肽水平的测量。双重葡萄糖耐量试验首次用于研究器质性高胰岛素血症患者的碳水化合物代谢。发现胰岛素瘤患者的该试验曲线与健康人相似，不过水平较低且末端部分下降更陡。这一特征可用于确定高胰岛素血症的起源。在该患者群体中，术前未检测到血糖、胰岛素和C肽水平之间存在相关性。术后这三个参数之间的失衡得以消除。术后碳水化合物代谢参数恢复正常；空腹试验中最低血糖水平升高了两倍。在高胰岛素血症消除后，短暂性高血糖持续了两周。术后第三周血糖水平的每日波动恢复正常。
