Pieters R H, Bol M, Penninks A H
Research Institute of Toxicology/Immunotoxicology Section, Utrecht University, The Netherlands.
Toxicology. 1994 Jul 1;91(2):189-202. doi: 10.1016/0300-483x(94)02793-5.
In the mid-seventies it appeared that some organotin compounds selectively caused thymus atrophy. From that time onward efforts were made to reveal molecular and cellular mechanisms involved. In this review recent studies into organotin-sensitive stages and processes of thymocyte maturation are discussed. Together these studies resulted in the recognition of organotin compounds as possible model compounds in studying immature thymocyte differentiation and protein synthesis-independent apoptotic cell death of thymocytes.
在20世纪70年代中期，一些有机锡化合物似乎会选择性地导致胸腺萎缩。从那时起，人们就致力于揭示其中涉及的分子和细胞机制。在这篇综述中，将讨论对有机锡敏感的胸腺细胞成熟阶段和过程的最新研究。这些研究共同促使人们认识到，有机锡化合物在研究未成熟胸腺细胞分化和胸腺细胞不依赖蛋白质合成的凋亡性细胞死亡方面可能是模型化合物。
