Ishimaru T, Masuzaki H, Samejima T, Fujishita A, Nakamura K, Yamabe T
Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, Japan.
Am J Obstet Gynecol. 1994 Aug;171(2):541-5. doi: 10.1016/0002-9378(94)90296-8.
This study examines the influence of ovarian endometrioma on fertility.
For 117 infertile women who were diagnosed as having endometriosis by laparoscopy and who underwent danazol therapy, we examined (1) the relationship between ovarian endometrioma and level of bead-phagocytotic macrophages in ascites and the interleukin-1 beta level, (2) the relationship between ovarian endometrioma and pregnancy rate during the 36 months after danazol therapy, and (3) the relationship between ovarian endometrioma and pregnancy rate, considering the severity of the lesion on the bilateral tubes and the pelvic peritoneum.
(1) The levels of bead-phagocytotic macrophages in patients with or without ovarian endometrioma were 68% and 67%, respectively (not significant). Similarly, no significant difference was seen in the interleukin-1 beta positive rate between the two groups. (2) The pregnancy rates of the former group and the latter group were 36% and 43%, respectively (not significant). (3) The existence or absence of ovarian endometrioma made no significant difference in the pregnancy rate in a group of patients with no lesions in the bilateral tubes or in another group with no lesions and scattered endometriotic implants on the peritoneum.
It seems unlikely that ovarian endometrioma itself significantly impedes fertility after danazol therapy.
本研究探讨卵巢子宫内膜异位囊肿对生育能力的影响。
对于117例经腹腔镜检查诊断为子宫内膜异位症并接受达那唑治疗的不孕女性，我们研究了：（1）卵巢子宫内膜异位囊肿与腹水中吞噬珠的巨噬细胞水平及白细胞介素-1β水平之间的关系；（2）卵巢子宫内膜异位囊肿与达那唑治疗后36个月内妊娠率之间的关系；（3）考虑双侧输卵管及盆腔腹膜病变严重程度的情况下，卵巢子宫内膜异位囊肿与妊娠率之间的关系。
（1）有或无卵巢子宫内膜异位囊肿患者的吞噬珠巨噬细胞水平分别为68%和67%（无显著差异）。同样，两组间白细胞介素-1β阳性率也无显著差异。（2）前一组和后一组的妊娠率分别为36%和43%（无显著差异）。（3）在双侧输卵管无病变的一组患者或腹膜无病变及散在子宫内膜异位种植灶的另一组患者中，卵巢子宫内膜异位囊肿的有无对妊娠率无显著影响。
达那唑治疗后，卵巢子宫内膜异位囊肿本身似乎不太可能显著阻碍生育能力。
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