原发性甲状旁腺功能亢进患者的红细胞膜钙转运

Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism.

作者信息

Vezzoli G, Reina M C, Cusi D, Casirati P, Soldati L, Azzani T, Muirhead R, Bianchi G

机构信息

Department of Nephrology Dialysis and Hypertension, University of Milan, Italy.

出版信息

Biochem Biophys Res Commun. 1994 Aug 15;202(3):1505-10. doi: 10.1006/bbrc.1994.2101.

DOI:10.1006/bbrc.1994.2101

PMID:8060333

Abstract

The chronic effect of PTH on erythrocyte membrane Ca transport was examined. (Ca+Mg)ATPase activity and passive Sr influx were measured to assess the rate of passive Ca influx (total and inhibited by dihydropyridines [DHPs]), in erythrocytes from patients with primary hyperparathyroidism and normal controls. Erythrocyte Sr influx was lower in patients, due to a decreased DHP-sensitive Sr influx. Conversely, efflux activity of (Ca+Mg)ATPase was not different in patients and controls. We hypothesize that in primary hyperparathyroidism chronic PTH stimulation may induce a downregulation of the erythrocyte Ca influx mediated by DHP-sensitive Ca carrier.

摘要

研究了甲状旁腺激素（PTH）对红细胞膜钙转运的慢性影响。测量了原发性甲状旁腺功能亢进患者和正常对照者红细胞中的（钙+镁）ATP酶活性和被动锶内流，以评估被动钙内流速率（总量以及受二氢吡啶类[DHPs]抑制的部分）。由于二氢吡啶敏感性锶内流降低，患者的红细胞锶内流较低。相反，患者和对照者的（钙+镁）ATP酶外流活性没有差异。我们推测，在原发性甲状旁腺功能亢进中，慢性PTH刺激可能导致由二氢吡啶敏感性钙载体介导的红细胞钙内流下调。