Jehle D, Fiorello A B, Brader E, Cottington E, Kozak R J
Department of Emergency Medicine, Erie County Medical Center, Buffalo, NY 14215.
Am J Emerg Med. 1994 Sep;12(5):524-6. doi: 10.1016/0735-6757(94)90269-0.
The objective of this study was to determine if hemoconcentration occurs during cardiac arrest and cardiopulmonary resuscitation (CPR). The design was an animal model of cardiac arrest and CPR performed at a research institute using six mongrel dogs. After the induction of cardiac arrest, animals were subjected to 4 minutes of ventricular fibrillation followed by 20 minutes of CPR. Resuscitation was then achieved using countershocks, drugs, and intravenous fluids. Hemoglobin concentrations were obtained before arrest and every 5 minutes during CPR. An average peak increase in hemoglobin concentration of 21% was observed during CPR. Hemoconcentration occurs during cardiac arrest and CPR, and this may be a result of a shift in volume from the intravascular to the extravascular space.
本研究的目的是确定在心脏骤停和心肺复苏（CPR）期间是否会发生血液浓缩。研究设计为在一家研究所使用6只杂种狗建立心脏骤停和CPR的动物模型。诱导心脏骤停后，让动物经历4分钟的室颤，随后进行20分钟的CPR。然后通过除颤、药物和静脉输液实现复苏。在心脏骤停前以及CPR期间每5分钟获取血红蛋白浓度。在CPR期间观察到血红蛋白浓度平均峰值增加了21%。在心脏骤停和CPR期间会发生血液浓缩，这可能是由于液体从血管内转移到血管外间隙所致。
