Neidle S
CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, U.K.
Ann Oncol. 1994;5 Suppl 4:51-4. doi: 10.1093/annonc/5.suppl_4.s51.
Determination of the three-dimensional molecular structures of proteins, enzymes and nucleic acids is the first step in the development of molecular models of drug-receptor complexes that may be used in the rational computer-aided design of new and sometimes novel inhibitors with altered recognition and receptor-affinity properties.
This approach provides a rational method for developing drugs that may be highly selective for a particular oncogene or other protein targets.
确定蛋白质、酶和核酸的三维分子结构是开发药物-受体复合物分子模型的第一步，这些模型可用于合理的计算机辅助设计新型且有时具有改变的识别和受体亲和力特性的抑制剂。
这种方法为开发可能对特定癌基因或其他蛋白质靶点具有高度选择性的药物提供了一种合理的方法。
