Peng Y G, Taylor T B, Finch R E, Switzer R C, Ramsdell J S
Marine Biotoxins Program, Medical University of South Carolina, Charleston 29412.
Neuroreport. 1994 Apr 14;5(8):981-5. doi: 10.1097/00001756-199404000-00032.
We have investigated the action of domoic acid in the mouse brain following systemic exposure. Domoic acid increased c-fos mRNA within 15 min and its translational product (c-Fos) within 1 h. c-Fos immunoreactivity was most prominent in the hippocampal formation, lateral septal nucleus, olfactory bulb, area postrema and the nucleus of the solitary tract. We next examined irreversible toxic effects of domoic acid. Domoic acid caused extensive degeneration in CA1-2 of the hippocampus, lateral septal nucleus and olfactory bulb. No degeneration was evident in the dentate gyrus or brain stem. These studies demonstrate that domoic acid has only neuroexcitatory effects on brain stem regions associated with visceral function whereas it has permanent neurotoxic effects on brain regions associated with memory formation.
我们研究了全身性暴露后软骨藻酸在小鼠脑中的作用。软骨藻酸在15分钟内增加c-fos mRNA，并在1小时内增加其翻译产物（c-Fos）。c-Fos免疫反应性在海马结构、外侧隔核、嗅球、最后区和孤束核中最为显著。接下来，我们检查了软骨藻酸的不可逆毒性作用。软骨藻酸导致海马CA1-2区、外侧隔核和嗅球广泛变性。齿状回或脑干未出现明显变性。这些研究表明，软骨藻酸对与内脏功能相关的脑干区域仅具有神经兴奋作用，而对与记忆形成相关的脑区具有永久性神经毒性作用。
