Kato H, Wakasugi H, Yokota M, Furukawa M, Mukuta T, Yamada Y, Funakoshi A
Department of Internal Medicine, National Kyushu Cancer Center, Fukuoka.
Intern Med. 1994 Mar;33(3):142-6. doi: 10.2169/internalmedicine.33.142.
Because it is difficult to diagnose at an early stage, pancreatic carcinoma is usually well advanced by the time it is diagnosed. The combined use of intraoperative radiotherapy, gastrointestinal and/or biliary tract bypass operation, celiac plexus nerve block, and chemotherapy is widely applied in treatment, with favorable results reported in some patients with advanced disease. To evaluate the efficacy of chemotherapy in such combinations, we compared the effect of 5-fluorouracil, its analogues, and mitomycin C on the survival of patients with advanced stage pancreatic cancer. We found no significant difference between the patients treated or not treated with these drugs. Clearly, there is a need for new agents having greater efficacy against pancreatic carcinoma.
由于胰腺癌在早期很难诊断，所以通常在确诊时病情已发展到较严重阶段。术中放疗、胃肠道和/或胆道旁路手术、腹腔神经丛神经阻滞以及化疗的联合应用在治疗中被广泛采用，一些晚期患者报告取得了良好效果。为评估化疗在这些联合治疗中的疗效，我们比较了5-氟尿嘧啶、其类似物和丝裂霉素C对晚期胰腺癌患者生存率的影响。我们发现接受或未接受这些药物治疗的患者之间没有显著差异。显然，需要有对胰腺癌更有效的新药物。
