Waller M, Pierce J C, Lee H M, Levinson H J
Transplantation. 1975 Mar;19(3):210-8. doi: 10.1097/00007890-197503000-00003.
Sequential titers of five different humoral antibodies (antirat erythrocyte, antisheep erythrocyte, isoantibodies, rheumatoid factors, and serum agglutinators) were simultaneously performed on 20 patients with renal transplants, 12 patients with skin transplants, and 2 patient populations (one hospitalized and one ambulatory). The results suggested that rises in titer of any of these antibodies could not be used as an indicator of acute rejection. Nevertheless, patients who lacked rejection episodes were unlikely to show humoral responses and always lacked antiglobulin responses. Heterophil responses always preceeded antiglobulin responses. These results suggest that heterophils are cross reacting antibodies and antiglobulins are auxillary immune responses.
对20例肾移植患者、12例皮肤移植患者以及2组患者群体（一组住院患者和一组门诊患者）同时进行了五种不同体液抗体（抗大鼠红细胞抗体、抗绵羊红细胞抗体、同种抗体、类风湿因子和血清凝集素）的连续滴度检测。结果表明，这些抗体中任何一种抗体滴度的升高都不能用作急性排斥反应的指标。然而，没有排斥反应发作的患者不太可能出现体液反应，并且总是缺乏抗球蛋白反应。嗜异性抗体反应总是先于抗球蛋白反应。这些结果表明，嗜异性抗体是交叉反应抗体，而抗球蛋白是辅助免疫反应。
