6α-[¹⁸F]氟孕酮的合成：迈向正电子发射断层显像（PET）潜在受体配体的第一步。
Synthesis of 6 alpha-[18F]fluoroprogesterone: a first step towards a potential receptor-ligand for PET.
作者信息
De Groot T J, Braker A H, Elsinga P H, Visser G M, Vaalburg W
机构信息
PET Center, University of Groningen, University Hospital, The Netherlands.
出版信息
Appl Radiat Isot. 1994 Jul;45(7):811-3. doi: 10.1016/0969-8043(94)90134-1.
PMID:8061663
Abstract
6 alpha-[18F]Fluoroprogesterone 3 was prepared by the BF3.Et2O-catalyzed reaction of progest-5 alpha, 6 alpha-epoxy-3,20-bisketal 1 and [18F]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mumol (100 Ci/mol, EOS).
摘要
通过BF₃·Et₂O催化的孕甾-5α,6α-环氧-3,20-双缩酮1与[¹⁸F]氟化物的反应制备了6α-[¹⁸F]氟孕酮3，作为通过正电子发射断层扫描（PET）在体内可视化孕酮受体的一种可能途径。3的放射化学产率为25%（放化纯），比活度为5 MBq/μmol（100 Ci/mol，放化终态）。
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