Lehmann E D, Hopkins K D, Parker J R, Turay R C, Rymer J, Fogelman I, Gosling R G
Division of Radiological Sciences, U.M.D.S. (University of London), Guy's Hospital, UK.
Br J Radiol. 1994 Jul;67(799):701-5. doi: 10.1259/0007-1285-67-799-701.
Both oestrogen and androgens have been shown to affect the structural composition and biophysical properties of the arterial wall in vitro. A non-invasive Doppler ultrasound technique, based on the measurement of pulse wave velocity along the thoraco-abdominal aortic pathway, was used to assess aortic compliance C in vivo in 49 normotensive, normal, healthy post-menopausal female subjects. 23 of the women had been receiving Tibolone, a synthetic steroid structurally related to norethisterone, for at least 3 years. Since C varies with non-chronic changes in blood pressure, an index of intrinsic aortic distensibility, Cp, normally independent of blood pressure, was also calculated. No significant difference was found between the control group and those subjects receiving Tibolone for age, body mass index, systolic blood pressure, diastolic blood pressure, C or Cp. As one would expect the control group Cp values did not show a significant relationship with blood pressure (r = -0.1, not significant). However, in the Tibolone group some dependence of Cp values on pressure still remained (r = -0.58, p < 0.004), suggesting that oral administration of Tibolone had altered the dynamic relationship between structural and functional biophysical properties of the aortic wall in vivo.
雌激素和雄激素在体外均已被证明会影响动脉壁的结构组成和生物物理特性。一种基于测量沿胸腹主动脉路径脉搏波速度的非侵入性多普勒超声技术，被用于评估49名血压正常、健康的绝经后女性受试者体内的主动脉顺应性C。其中23名女性至少3年来一直在服用替勃龙，一种在结构上与炔诺酮相关的合成类固醇。由于C会随血压的非慢性变化而改变，因此还计算了通常独立于血压的固有主动脉扩张性指数Cp。在年龄、体重指数、收缩压、舒张压、C或Cp方面，对照组与服用替勃龙的受试者之间未发现显著差异。正如预期的那样，对照组的Cp值与血压之间未显示出显著关系（r = -0.1，不显著）。然而，在替勃龙组中，Cp值对压力仍存在一定依赖性（r = -0.58，p < 0.004），这表明口服替勃龙改变了体内主动脉壁结构和功能生物物理特性之间的动态关系。
