Lewis J A
Institute of Mathematics and Statistics, University of Kent at Canterbury, UK.
Cardiology. 1994;84(6):385-90.
Over the past 20 years, large mortality trials have become an increasingly prominent feature of cardiovascular research. The numbers of patients enrolled in the trials has increased, and the quality of research has improved in line with recent methodological advances. This paper reviews important aspects of the design and analysis of key clinical studies and assesses the impact of the results of clinical trials on clinical practice.
在过去20年里，大型死亡率试验已成为心血管研究中日益突出的特征。参与试验的患者数量有所增加，并且研究质量也随着近期方法学的进步而提高。本文回顾了关键临床研究设计与分析的重要方面，并评估了临床试验结果对临床实践的影响。
