Kawahito S, Ueda S, Ishida M, Nakamura T, Usui S, Nagaoka S
Department of Information and Computer Sciences, Toyohashi University of Technology, Japan.
IEEE Trans Biomed Eng. 1994 Apr;41(4):400-6. doi: 10.1109/10.284972.
A CMOS integrated circuit for a noninvasive biological-signal telemetry system specified for use in medical and physiological studies of the influence of weightlessness in space is presented. The system can monitor multichannel (4 channels maximum) biological signals from multiple subjects (4 subjects maximum) in real time by using time multiplexing. A key technique, so-called synchronized multiple-subject telemetry, to achieve multiple-subject telemetry has been proposed. This technique utilizes bidirectional optical transmissions with direct and scattered infrared lights between an observer and each of the subjects. An experimental CMOS IC to give a small light-weight low-power, and smart telemetry instrument for use on animals has been developed. This IC is for evaluating circuit blocks of the implantable monolithic telemetry instrument. The major circuit blocks include CMOS digital circuits for synchronization, subject selection and time multiplexing, analog circuits for pulse interval modulation (PIM), and other blocks such as a CMOS optical pulse receiver and an LED driver. A preliminary experimental multichannel telemetry from two subjects has been performed with the implemented IC chips, and the principal operation of the multiple-subject optical biotelemetry has been demonstrated.
本文介绍了一种用于非侵入式生物信号遥测系统的CMOS集成电路，该系统专为太空失重影响的医学和生理学研究而设计。该系统可以通过时分复用实时监测来自多个受试者（最多4个受试者）的多通道（最多4通道）生物信号。为实现多受试者遥测，提出了一种关键技术，即所谓的同步多受试者遥测。该技术利用观察者与每个受试者之间的直接和散射红外光进行双向光传输。已开发出一种实验性CMOS集成电路，用于制造小型、轻质、低功耗且智能的动物遥测仪器。该集成电路用于评估植入式单片遥测仪器的电路模块。主要电路模块包括用于同步、受试者选择和时分复用的CMOS数字电路、用于脉冲间隔调制（PIM）的模拟电路，以及诸如CMOS光脉冲接收器和LED驱动器等其他模块。使用已实现的集成电路芯片对两个受试者进行了初步的实验性多通道遥测，并展示了多受试者光学生物遥测的主要操作。
