Golterman A F, de Vries R A, van Stuivenberg A, Gill R D
Hospital Gelderse Vallei, Department of Internal Medicine, Bennekom, The Netherlands.
Int J Biomed Comput. 1994 May;35(4):231-45.
To obtain an adequate curve fitting of labeled platelets also in case of severe pathology the multiple hit model of Murphy & Francis can be used, however, with addition of fractions of n (argument of the gamma function) and expansion of the domain of n towards zero and negative values. The 'hazard rate function' provides the instantaneous death rate for a platelet that has survived up to a given time. Applied to the multiple hit function, three kinds of hazard rate will be found: for n > 1 the death rate increases with age (absent or moderate pathology); for n = 1 the death rate is independent of age (death at random); for n < 1 the death rate decreases with age (probably severe pathology).
为了即使在严重病变的情况下也能获得标记血小板的充分曲线拟合，可以使用墨菲和弗朗西斯的多重打击模型，不过，要增加n（伽马函数的自变量）的分数，并将n的定义域扩展到零和负值。“风险率函数”给出了存活到给定时间的血小板的瞬时死亡率。应用于多重打击函数时，会发现三种风险率：当n>1时，死亡率随年龄增加（无病变或病变较轻）；当n = 1时，死亡率与年龄无关（随机死亡）；当n<1时，死亡率随年龄降低（可能是严重病变）。
