Kimura I, Tanizaki Y, Sato S, Takahashi K, Saito K
Clin Allergy. 1975 Jun;5(2):181-7. doi: 10.1111/j.1365-2222.1975.tb01851.x.
The morphological changes in blood basophils, from patients with bronchial asthma, were studied in vitro during immunological reactions, with particular reference to interaction with anti-IgE. Anti-human IgE results in an absolute reduction in basophil numbers in buffy coat preparations as well as basophil cytoplasmic degranulation. An increase in the number of pear-shaped (A-form) basophils is also observed. Sodium cromoglycate impairs all these anti-IgE induced basophil changes, providing further insight into the mechanism of action of this compound in bronchial asthma.
对支气管哮喘患者血液嗜碱性粒细胞在体外免疫反应过程中的形态变化进行了研究，特别关注其与抗IgE的相互作用。抗人IgE导致血沉棕黄层制剂中嗜碱性粒细胞数量绝对减少以及嗜碱性粒细胞胞质脱颗粒。还观察到梨形（A形）嗜碱性粒细胞数量增加。色甘酸钠会损害所有这些抗IgE诱导的嗜碱性粒细胞变化，这为该化合物在支气管哮喘中的作用机制提供了进一步的见解。
