一种用于多机构临床试验的灵活随机分配程序。

A flexible random allocation program for multi-institutional clinical trials.

作者信息

Odaka T, Akazawa K, Watanabe Y, Nose Y, Ogura H

机构信息

Department of Information Science, Faculty of Engineering, Fukui University.

出版信息

J Med Syst. 1994 Feb;18(1):39-53. doi: 10.1007/BF00999323.

DOI:10.1007/BF00999323

PMID:8064207

Abstract

This paper describes a flexible random allocation program that assigns treatments to patients according to their prognostic factors in multi-institutional clinical trials. The source lists are available in the appendix of this paper. This program is based on Pocock and Simon's minimization method and Zelen's method for institution balancing. The numbers of institutions, treatments, and prognostic factors can be set arbitrarily. The maximum number of institutions, treatments, or prognostic factors that can be accommodated by the program is limited only by the size of the main memory. For example, an IBM-PC with a 640KB main memory can run a program of 1500 institutions, 4 treatments and 20 prognostic factors.

摘要

本文描述了一种灵活的随机分配程序，该程序在多机构临床试验中根据患者的预后因素为其分配治疗方案。来源列表可在本文附录中获取。该程序基于波科克和西蒙的最小化方法以及泽伦的机构平衡方法。机构、治疗方案和预后因素的数量可以任意设定。该程序能够容纳的机构、治疗方案或预后因素的最大数量仅受主存大小的限制。例如，一台具有640KB主存的IBM个人电脑可以运行一个包含1500个机构、4种治疗方案和20个预后因素的程序。