Kuroe K, Kurahashi K, Nakano I, Morimatsu Y, Takemori H
First Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
J Neurol Sci. 1994 May;123(1-2):59-63. doi: 10.1016/0022-510x(94)90204-6.
Neuropathological examination in a 48-year-women of SLE with chorea was performed. Histological examination of the putamen showed a widespread neuronal loss associated with reactive astrocyte proliferation and neuropil rarefaction at both sides. Disappearance of large neurons was more prominent than that of small ones. Although a few old and fresh microinfarcts were scattered in the same area, there was no significant pathological abnormality in small vessels. The caudate nuclei also showed a few irregular microinfarcts and spotty loss of neurons associated with reactive astrocytosis. These neuropathological changes might be related to the appearance of choreatic movement in patients with SLE.
