Lezcano L, Antia D E, Sahdev S, Jhaveri M
Department of Pediatrics, Elmhurst Hospital Center, Mount Sinai School of Medicine, N.Y.
J Perinatol. 1994 May-Jun;14(3):230-3.
Although cocaine abuse has declined in popularity in the United States, certain groups continue to use the drug at high rates. The teratogenicity of cocaine has been widely investigated in the newborn. We report a case of crossed renal ectopia in a term neonate whose mother practiced alkaloid cocaine abuse in the first trimester of pregnancy. We propose that this anomaly was caused by cocaine's direct pharmacologic effect, leading to vasoconstriction that affected the developing fetal kidney by compromising the blood vessels that supply the organ or by causing hemorrhages and infarctions with fibrosis, causing disruption during a crucial period of morphogenesis.
尽管在美国，可卡因滥用现象已不如以往普遍，但某些群体仍在高频率使用这种毒品。可卡因对新生儿的致畸性已得到广泛研究。我们报告了一例足月新生儿交叉异位肾的病例，其母亲在妊娠早期有生物碱可卡因滥用史。我们认为这种异常是由可卡因的直接药理作用引起的，导致血管收缩，通过损害供应该器官的血管，或引起出血、梗死并伴有纤维化，从而在形态发生的关键时期造成干扰，进而影响发育中的胎儿肾脏。
