Ono S, Nohara R, Kambara H, Okuda K, Mohiuddin I H, Tamaki N, Konishi J
Department of Internal Medicine, Kyoto University Faculty of Medicine.
J Cardiol. 1993;23(4):365-70.
Positron emission tomography (PET) with C-11 acetate allows noninvasive quantification of myocardial oxidative metabolism. To assess the myocardial metabolic reserve, clearance of C-11 acetate from the myocardium was measured with PET in 8 normal subjects at rest and during the infusion of dobutamine (inotropic agent) or dipyridamole (vasodilator). During dobutamine infusion, the clearance rate constant of C-11 acetate increased significantly (0.063 +/- 0.014 vs 0.109 +/- 0.016, p < 0.002) in good correlation with the rate-pressure product (r = 0.83). During dipyridamole infusion, myocardial acetate clearance also significantly increased (0.088 +/- 0.024, p < 0.05) in correlation with the rate-pressure product (r = 0.54). In normal myocardium, myocardial oxidative metabolism increased in response to increased work load with pharmacological stress. These findings suggest that PET with C-11 acetate and pharmacological stress may be a promising approach for the evaluation of metabolic reserve in patients with ischemic heart disease.
用碳-11 乙酸盐进行正电子发射断层扫描（PET）可对心肌氧化代谢进行无创定量分析。为评估心肌代谢储备，在静息状态以及静脉输注多巴酚丁胺（强心剂）或双嘧达莫（血管扩张剂）期间，对 8 名正常受试者用 PET 测量心肌中碳-11 乙酸盐的清除情况。在输注多巴酚丁胺期间，碳-11 乙酸盐的清除率常数显著增加（0.063±0.014 对比 0.109±0.016，p<0.002），与心率-血压乘积密切相关（r = 0.83）。在输注双嘧达莫期间，心肌乙酸盐清除率也显著增加（0.088±0.024，p<0.05），与心率-血压乘积相关（r = 0.54）。在正常心肌中，心肌氧化代谢随药理学应激下工作负荷增加而增强。这些发现表明，用碳-11 乙酸盐进行 PET 检查及药理学应激可能是评估缺血性心脏病患者代谢储备的一种有前景的方法。
