Zubieta J K, Engleberg N C, Yargiç L I, Pande A C, Demitrack M A
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109-0116.
J Psychiatr Res. 1994 Jan-Feb;28(1):13-22. doi: 10.1016/0022-3956(94)90033-7.
The psychobiology of idiopathic fatigue has received renewed interest in the medical literature in recent years. In order to examine the relation between chronic, idiopathic fatigue and specific subtypes of depressive illness, we characterized the pattern and severity of seasonal symptom variation in 73 patients with chronic, idiopathic fatigue, compared to patients with major depression (n = 55), atypical depression (n = 35), and seasonal affective disorder (n = 16) Fifty of the fatigued subjects also met the specific Centers for Disease Control and Prevention case criteria for chronic fatigue syndrome, though this definition was unable to discriminate a distinct subgroup of patients, based on their seasonality scores alone. As a group, the fatigued subjects reported the lowest levels of symptom seasonality of any of the study groups. Further, even in those fatigued subjects with scores in the range of those seen in patients with seasonal affective disorder, seasonality was not reported to be a subjectively distressing problem. These findings lend support to the idea that although chronic fatigue shares some clinical features with certain mood disorders, they are not the same illnesses. These data are also consistent with the emerging view that chronic fatigue represents a heterogeneously determined clinical condition.
近年来，特发性疲劳的心理生物学在医学文献中重新受到关注。为了研究慢性特发性疲劳与特定类型抑郁症之间的关系，我们对73例慢性特发性疲劳患者的季节性症状变化模式和严重程度进行了特征分析，并与重度抑郁症患者（n = 55）、非典型抑郁症患者（n = 35）和季节性情感障碍患者（n = 16）进行了比较。50名疲劳受试者也符合美国疾病控制与预防中心慢性疲劳综合征的特定病例标准，不过仅根据季节性得分，该定义无法区分出一个独特的患者亚组。作为一个群体，疲劳受试者报告的症状季节性水平在所有研究组中是最低的。此外，即使在那些得分处于季节性情感障碍患者范围内的疲劳受试者中，季节性也未被报告为一个主观困扰问题。这些发现支持了这样一种观点，即尽管慢性疲劳与某些情绪障碍有一些临床特征相同，但它们并非同一种疾病。这些数据也与新出现的观点一致，即慢性疲劳代表一种由多种因素决定的临床状况。
