接受环磷酰胺、放线菌素D和5-氟尿嘧啶化疗方案的犬出现意外神经毒性。
Unexpected neurotoxicity in dogs receiving a cyclophosphamide, dactinomycin, and 5-fluorouracil chemotherapy protocol.
作者信息
Hammer A S, Carothers M A, Harris C L, O'Keefe D A, Ayl R D, Peterson J L, Shank K A, Couto C G
机构信息
Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210.
出版信息
J Vet Intern Med. 1994 May-Jun;8(3):240-3. doi: 10.1111/j.1939-1676.1994.tb03225.x.
An inexpensive combination chemotherapy protocol containing cyclophosphamide, dactinomycin, and 5-fluorouracil was evaluated in dogs with carcinomas. Fifteen dogs were entered in this study, and there were 1 complete response and 2 partial responses among 12 evaluable dogs. However, 6 of 15 dogs (40%) developed neurotoxicity. The neurotoxicity of this protocol was compared with a previous 5-fluorouracil-containing protocol and found to be significantly higher. Due to the unacceptably high rate of neurotoxicity, this protocol cannot be recommended for use in dogs with cancer.
一种包含环磷酰胺、放线菌素D和5-氟尿嘧啶的低成本联合化疗方案在患有癌症的犬类中进行了评估。15只犬参与了本研究，在12只可评估的犬中，有1只完全缓解，2只部分缓解。然而，15只犬中有6只（40%）出现了神经毒性。该方案的神经毒性与之前含5-氟尿嘧啶的方案进行了比较，发现明显更高。由于神经毒性发生率高得令人无法接受，该方案不推荐用于患癌犬类。
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