Da Silva J A, Willoughby D A
Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, UK.
J Rheumatol. 1994 May;21(5):791-6.
Sex emerges as a predominant risk and prognostic factor from epidemiological studies in a variety of rheumatic diseases. Investigations into the underlying mechanisms stress sex related differences in immune and inflammatory responses. Cartilage destruction is an essential feature of most arthropathies and plays an essential role in the symptomatology and progression of arthritis. Based on published evidence and recent experimental observations, we explore the possibility that sex differences in articular cartilage may be an important, though unrecognized, factor in the effects of sex and related hormones in the progression of articular disease.
在各种风湿性疾病的流行病学研究中，性别已成为一个主要的风险和预后因素。对潜在机制的研究强调了免疫和炎症反应中与性别相关的差异。软骨破坏是大多数关节病的一个基本特征，在关节炎的症状表现和进展中起着重要作用。基于已发表的证据和最近的实验观察结果，我们探讨了关节软骨中的性别差异可能是性别及相关激素在关节疾病进展中产生影响的一个重要但未被认识到的因素的可能性。
