Dillon M J
Renal Unit, Hospital for Sick Children, London, UK.
J Hum Hypertens. 1994 May;8(5):367-9.
Renovascular disease constitutes approximately 10% of cases of secondary hypertension in childhood. It is associated with neurofibromatosis and a number of other syndromes. Fibromuscular dysplasia is the commonest histopathological finding. Bilateral and intrarenal disease is common and is associated with extrarenal arterial disease in a significant proportion of cases. Utilizing currently available investigative procedures, the nature of the disease can be defined and decisions made regarding appropriate treatment. However, although there is the potential for surgical cure, a substantial number of children still require medical therapy probably due to the high incidence of bilateral and small intrarenal arterial involvement that is not amenable to surgical or angioplasty treatment.
肾血管疾病约占儿童继发性高血压病例的10%。它与神经纤维瘤病及其他多种综合征有关。纤维肌性发育异常是最常见的组织病理学表现。双侧及肾内疾病较为常见，且在相当比例的病例中与肾外动脉疾病相关。利用现有的检查方法，可以明确疾病的性质并就适当的治疗做出决策。然而，尽管有可能通过手术治愈，但仍有相当数量的儿童可能由于双侧及肾内小动脉受累的发生率较高而无法接受手术或血管成形术治疗，仍需要药物治疗。
