Hansen P D, Coffey S C, Lewis F R
Department of General Surgery, University of California at San Francisco.
J Trauma. 1994 Aug;37(2):283-91; discussion 291-3. doi: 10.1097/00005373-199408000-00022.
This study measured changes in whole body Do2 and Vo2 caused by the administration of exogenous adrenergic agents given at physiologically relevant doses. Using 25-kg nonseptic dogs, we calculated Do2 and directly measured Vo2 in six groups (saline control, colloid fluid challenge, dopamine, dobutamine, norepinephrine, and epinephrine). The dogs were anesthetized with isoflurane, paralyzed, and maintained at a minimum baseline temperature of 37 degrees C. Measurements were taken at six time points: baseline, after each of four successively larger doses of drug, and after a recovery period. Our results demonstrated no significant changes in Vo2 in either the saline control or colloid challenge groups over the 6-hour experiment despite marked increases in cardiac output and oxygen delivery during colloid challenge. At the maximum dose used, adrenergic agents increased Vo2 by the following: dopamine, 56%; dobutamine, 51%; norepinephrine, 43%; epinephrine, 61%. We conclude that adrenergic agents cause a significant increase in whole body Vo2 at moderate doses in normal dogs.
本研究测量了给予生理相关剂量的外源性肾上腺素能药物后全身氧输送（Do2）和氧耗（Vo2）的变化。我们使用25千克非脓毒症犬，在六组（生理盐水对照组、胶体液冲击组、多巴胺组、多巴酚丁胺组、去甲肾上腺素组和肾上腺素组）中计算Do2并直接测量Vo2。犬用异氟烷麻醉、麻痹，并维持最低基线体温37摄氏度。在六个时间点进行测量：基线、给予四次剂量依次增大的药物后各一次，以及恢复期后。我们的结果表明，在6小时的实验中，生理盐水对照组或胶体冲击组的Vo2均无显著变化，尽管胶体冲击期间心输出量和氧输送显著增加。在所用的最大剂量下，肾上腺素能药物使Vo2增加如下：多巴胺，56%；多巴酚丁胺，51%；去甲肾上腺素，43%；肾上腺素，61%。我们得出结论，在正常犬中，中等剂量的肾上腺素能药物会导致全身Vo2显著增加。
