Liapi-Avgeri G, Karabela-Bouropoulou V, Agnanti N
Department of Pathology KAT District General Hospital, University of Ioannina, Greece.
Pathol Res Pract. 1994 Jan;190(1):2-10. doi: 10.1016/S0344-0338(11)80490-5.
Glomus tumors are benign lesions composed of vessels and glomocytes in varying proportions. The histological appearance of the tumors depend upon the ratio of the vascular to the glomus cells and their differentiation as well as upon the amount and composition of the stroma. The aim of the present study was the establishment of criteria for the distinction of glomus tumor-like malformations from neoplasms with glomus cell differentiation. Using a panel of monoclonal and polyclonal antibodies (vimentin, a-smooth muscle actin, desmin, pan-keratin, low molecular weight cytokeratin, EMA, NSE, S-100 protein, Factor VIII, a1-ACT) glomus tumors could be separated into three types: vascular, cellular with myxoid stroma and cellular, solid type. In the first two types the tumor growth is composed of all three components found in normal glomus body, but in a haphazard fashion and thus might be considered as tumor-like malformations. The third type is composed of perivascular arranged cells most of which acquire the phenotypical characteristics of glomocytes. This last tumor probably represent the neoplastic variant of the group of lesions designated by the term glomus tumor.
血管球瘤是由血管和不同比例的血管球细胞组成的良性病变。肿瘤的组织学表现取决于血管与血管球细胞的比例及其分化情况，以及间质的数量和组成。本研究的目的是建立区分血管球瘤样畸形与具有血管球细胞分化的肿瘤的标准。使用一组单克隆和多克隆抗体（波形蛋白、α-平滑肌肌动蛋白、结蛋白、泛角蛋白、低分子量细胞角蛋白、上皮膜抗原、神经元特异性烯醇化酶、S-100蛋白、因子VIII、α1-抗胰蛋白酶），血管球瘤可分为三种类型：血管型、伴有黏液样间质的细胞型和实体细胞型。在前两种类型中，肿瘤生长由正常血管球体内发现的所有三种成分组成，但排列杂乱无章，因此可被视为肿瘤样畸形。第三种类型由血管周围排列的细胞组成，其中大多数具有血管球细胞的表型特征。最后这种肿瘤可能代表了被称为血管球瘤的病变组中的肿瘤变体。
