Bearzi I, Brancorsini D, Santinelli A, Rezai B, Mannello B, Ranaldi R
Institute of Pathology, University of Ancona, Italy.
Pathol Res Pract. 1994 Jan;190(1):61-8. doi: 10.1016/s0344-0338(11)80497-8.
The results of a ten-year follow-up study on gastric dysplasia (GD) are reported. A total of 260 cases were diagnosed, 125 of which had an adequate follow-up, 81 Low Grade Dysplasia (LGD) and 44 High Grade Dysplasia (HGD). Patients with LGD were younger than patients with HGD, while no significant difference in the mean age was found between HGD and carcinoma. LGD regressed in 49.4% of cases, persisted in 18.5% and progressed in 32.1%. HGD regressed in 4.6%, persisted in 13.6% and progressed in 81.8%. In some cases dysplasia reappeared after a long-time interval of apparent regression. In 58 cases progression to cancer was observed: in 35 cases dysplasia was associated with carcinoma (8 LGD and 27 HGD), while in 23 cases dysplasia evolved into carcinoma (14 LGD and 9 HGD). There was a good correlation between the accuracy in following up the patients and the chance of diagnosing the carcinoma at an early stage. The importance of gastric dysplasia as a marker for carcinoma, its precancerous nature and the treatment of the patients are discussed.
报告了一项关于胃发育异常（GD）的十年随访研究结果。共诊断出260例病例，其中125例进行了充分随访，81例为低级别发育异常（LGD），44例为高级别发育异常（HGD）。LGD患者比HGD患者年轻，而HGD与癌之间的平均年龄无显著差异。LGD在49.4%的病例中消退，18.5%持续存在，32.1%进展。HGD在4.6%的病例中消退，13.6%持续存在，81.8%进展。在一些病例中，发育异常在明显消退的长时间间隔后再次出现。观察到58例进展为癌症：35例发育异常与癌相关（8例LGD和27例HGD），而23例发育异常演变为癌（14例LGD和9例HGD）。患者随访的准确性与早期诊断癌症的机会之间存在良好的相关性。讨论了胃发育异常作为癌的标志物的重要性、其癌前性质以及患者的治疗。
