Tyagi K, Murthy P K, Chatterjee R K
Central Drug Research Institute, Lucknow, India.
Trop Med Parasitol. 1994 Mar;45(1):24-6.
The effect of immunopotentiators (Freund's complete adjuvant and CDRI Compound no. 84/201) has been evaluated on exertion of antifilarial activity of diethylcarbamazine (DEC) at different dose levels in Mastomys natalensis experimentally infected with Brugia malayi. DEC alone exhibited dose dependent micro- as well as macrofilarial action. In combination with immunomodulators, activity of DEC was significantly enhanced even at a lower dose level (12.5 mg/kg). However at higher dose level (> 25 mg/kg) of the drug along with immunostimulator the adulticidal activity was significantly reduced. Nevertheless, immunopotentiators themselves displayed certain amount of antifilarial action (34-38% macrofilaricidal).
在实验感染马来布鲁线虫的罗非鼠中，已评估免疫增强剂（弗氏完全佐剂和中央药物研究所化合物84/201）对不同剂量水平的乙胺嗪（DEC）抗丝虫活性发挥的作用。单独使用DEC表现出剂量依赖性的微丝蚴和成虫作用。与免疫调节剂联合使用时，即使在较低剂量水平（12.5毫克/千克），DEC的活性也显著增强。然而，在该药物较高剂量水平（>25毫克/千克）与免疫刺激剂联合使用时，成虫杀灭活性显著降低。尽管如此，免疫增强剂本身显示出一定程度的抗丝虫作用（34%-38%的成虫杀灭率）。
