坦桑尼亚沿海地区对氯喹耐药的恶性疟原虫。对以村庄为基础的疟疾化疗控制持续策略的一项挑战。
Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control.
作者信息
Premji Z, Minjas J N, Shiff C J
机构信息
Muhimbili University College of Health Science, Dar es Salaam, Tanzania.
出版信息
Trop Med Parasitol. 1994 Mar;45(1):47-8.
An in vivo study to assess Plasmodium falciparum sensitivity to chloroquine was conducted in two villages of the Bagamoyo District, Tanzania in December 1992. The WHO standard field test (7 days) and the extended test (28 days) were carried out on symptom free children. The presence of chloroquine resistance was confirmed with 59% of infections being found resistant. Fifty-three percent were RI, 2% were at RII and 4% at RIII levels of resistance. Dosage was 25 mg/kg chloroquine base delivered over three days.
1992年12月，在坦桑尼亚巴加莫约区的两个村庄开展了一项评估恶性疟原虫对氯喹敏感性的体内研究。对无症状儿童进行了世卫组织标准现场测试（7天）和延长测试（28天）。证实存在氯喹耐药性，59%的感染被发现耐药。53%为RI，2%为RII，4%为RIII耐药水平。剂量为25mg/kg氯喹碱，分三天服用。
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