Odriozola E, Campero C, Casaro A, Lopez T, Olivieri G, Melucci O
Grupo de Sanidad Animal, Estacion Experimental Agropecuaria Balcarce, INTA, Argentina.
Vet Hum Toxicol. 1994 Jun;36(3):205-8.
A herd of 135 Aberdeen Angus cows were grazing on pastures containing abundant Senecio selloi in the eastern region of Buenos Aires Province, Argentina. Some undiagnosed deaths were observed during 1989. In 1990 the death count raised to 38 animals, all of them showing the same clinical signs and gross and histopathological lesions. The time from the start of signs to death varied from 2 to 6 d. The most conspicuous signs were distention of the abdominal cavity and moderate icterus of mucous membranes. At necropsy, large amounts of fluid were in the abdominal cavity, there were lesions in the digestive tract, kidneys and mesenteric lymph nodes, and the liver was enlarged and fibrous. Histopathology showed the hepatic parenchyma replaced by fibrous tissue with marked megalocytosis. The signs and lesions were consistent with those produced by pyrrolizidine alkaloids. An abundance of Senecio selloi resulted in a diagnosis of poisoning from this plant. This is the first report of toxicity due to this plant species in Argentina.
在阿根廷布宜诺斯艾利斯省东部地区，一群135头阿伯丁安格斯奶牛在长满大量赛氏千里光的牧场上吃草。1989年期间观察到一些不明原因的死亡。1990年，死亡数量增至38头，所有死亡奶牛都表现出相同的临床症状、大体病变和组织病理学病变。从出现症状到死亡的时间为2至6天。最明显的症状是腹腔膨胀和黏膜中度黄疸。尸检时，腹腔内有大量液体，消化道、肾脏和肠系膜淋巴结有病变，肝脏肿大且纤维化。组织病理学显示肝实质被纤维组织取代，伴有明显的巨细胞增多症。这些症状和病变与吡咯里西啶生物碱所致的相符。大量的赛氏千里光导致诊断为该植物中毒。这是阿根廷关于该植物物种毒性的首次报告。
