Rokicka-Milewska R, Derulska D, Pawelec K
Katedry i Kliniki Pediatrii, Hematologii i Onkologii AM w Warszawie.
Acta Haematol Pol. 1994;25(2):111-8.
15 children with ALL and chemotherapy related neutropenia were treated with GM-CSF (Leucomax-Sandoz/Schering-Plough) in a dose of 5 micrograms/kg b.w./day during 7-10 days. Altogether 21 cycles were performed. Increase in the number of neutrophils in the majority of cases was observed already after 3 days of GM-CSF administration. The median time of neutropenia recovery was shorter in children treated with GM-CSF than in the control group. The frequency of severe infections was also significantly lower. No serous side effects were observed.
15名患有急性淋巴细胞白血病（ALL）且伴有化疗相关性中性粒细胞减少症的儿童接受了粒细胞巨噬细胞集落刺激因子（GM-CSF，沙多兹公司/先灵葆雅公司生产的乐白吉）治疗，剂量为5微克/千克体重/天，持续7至10天。共进行了21个疗程。在大多数病例中，GM-CSF给药3天后即观察到中性粒细胞数量增加。接受GM-CSF治疗的儿童中性粒细胞减少症恢复的中位时间比对照组短。严重感染的发生率也显著更低。未观察到严重的副作用。
