Gebber G L, Zhong S, Barman S M, Orer H S
Department of Pharmacology/Toxicology, Michigan State University, East Lansing 48824-11317.
Am J Physiol. 1994 Aug;267(2 Pt 2):R400-7. doi: 10.1152/ajpregu.1994.267.2.R400.
Partial coherence analysis was used to remove the influences of pulse-synchronous baroreceptor nerve activity (as reflected by the arterial pulse) on the coherence of the cardiac-related discharges of sympathetic nerve pairs in unanesthetized decerebrate cats. It can be predicted that the peak at the heart rate frequency in the ordinary coherence function relating the discharges of two nerves will be eliminated by either partialization using the arterial pulse or surgical baroreceptor denervation, if the central circuits controlling the nerves share baroreceptor inputs but are not interconnected. Contrary to this prediction, in many experiments the peak was not eliminated by partialization using the arterial pulse. Moreover, partialization often nonuniformly reduced the peaks at the heart rate frequency in the coherence functions for different nerve pairs. These results are consistent with a model of multiple routes over which baroreceptor influences are distributed to the central circuits controlling different sympathetic nerves. Specifically, we propose that the direct route from the baroreceptors to each of the central circuits is complemented by cross talk among the central circuits.
在未麻醉的去大脑猫中，采用部分相干分析来消除脉搏同步压力感受器神经活动（由动脉脉搏反映）对交感神经对心脏相关放电相干性的影响。可以预测，如果控制神经的中枢回路共享压力感受器输入但不相互连接，那么使用动脉脉搏进行部分化或手术去除压力感受器神经支配，将消除与两条神经放电相关的普通相干函数中在心率频率处的峰值。与该预测相反，在许多实验中，使用动脉脉搏进行部分化并未消除该峰值。此外，部分化常常非均匀地降低了不同神经对相干函数中在心率频率处的峰值。这些结果与压力感受器影响通过多条路径分布到控制不同交感神经的中枢回路的模型一致。具体而言，我们提出从压力感受器到每个中枢回路的直接路径由中枢回路之间的串扰补充。
