Soloff P H, Lis J A, Kelly T, Cornelius J, Ulrich R
Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213.
Am J Psychiatry. 1994 Sep;151(9):1316-23. doi: 10.1176/ajp.151.9.1316.
This study identified potential risk factors for suicidal behavior in patients with borderline personality disorder defined by the Diagnostic Interview for Borderline Patients and by DSM-III-R criteria for patients who did and did not attempt suicide.
Histories of suicide attempts and attempt characteristics were obtained by Schedule for Affective Disorders and Schizophrenia interviews from 84 patients with borderline personality disorder and were related to severity of borderline pathology, diagnostic comorbidity, and state and trait symptoms.
There were 61 patients with a lifetime history of suicide attempts (72.6%), with an average of 3.39 (SD = 2.87) attempts per patient. Attempters were significantly older than nonattempters, with more impulse actions, antisocial personality disorder comorbidity, and state depression. State depression was significantly less severe in patients who had attempted suicide in the present episode (or past year) than in patients who had attempted suicide only in the past. A comorbid diagnosis of major depression, alcoholism, or drug use disorder did not distinguish attempters from nonattempters. Suicide attempt in the present episode was best predicted by the number of prior lifetime attempts. A highly serious intent to commit suicide was predicted by the number of lifetime attempts and subjective depression, while a low intent was predicted by a mixed subtype of borderline personality disorder plus schizotypal personality disorder and paranoid ideation. A high degree of medical lethality was predicted by number of lifetime attempts, older age, and hysteroid dysphoria, while low lethality attempts were associated with high degrees of anger.
Risk factors for suicidal behavior in patients with borderline personality disorder include older age, prior suicide attempts, antisocial personality, impulsive actions, and depressive moods but not comorbid affective disorder, alcoholism, or drug use disorders.
本研究确定了根据《边缘性患者诊断访谈》及《精神疾病诊断与统计手册》第三版修订版(DSM-III-R)标准界定的边缘性人格障碍患者中,自杀行为的潜在风险因素,这些患者有或没有自杀未遂经历。
通过情感障碍和精神分裂症访谈日程表,获取了84例边缘性人格障碍患者的自杀未遂史及未遂特征,并将其与边缘性病理严重程度、诊断共病情况以及状态和特质症状相关联。
有61例患者有终身自杀未遂史(72.6%),每位患者平均有3.39次(标准差=2.87)未遂经历。自杀未遂者明显比未未遂者年龄大,有更多冲动行为、反社会人格障碍共病以及状态性抑郁。当前发作期(或过去一年)有自杀未遂的患者,其状态性抑郁程度明显低于仅在过去有过自杀未遂的患者。重度抑郁、酒精中毒或药物使用障碍的共病诊断并不能区分自杀未遂者和未未遂者。当前发作期的自杀未遂情况,最好通过既往终身未遂次数来预测。终身未遂次数和主观抑郁可预测高度严重的自杀意图,而边缘性人格障碍混合亚型加分裂型人格障碍及偏执观念可预测低度意图。终身未遂次数、年龄较大以及类癔症性烦躁不安可预测高度医疗致死性的未遂行为,而低度致死性的未遂行为与高度愤怒相关。
边缘性人格障碍患者自杀行为的风险因素包括年龄较大、既往自杀未遂、反社会人格、冲动行为和抑郁情绪,但不包括共病情感障碍、酒精中毒或药物使用障碍。