Redmond L M, Cross D L, Strickland J R, Kennedy S W
Department of Animal, Dairy and Veterinary Sciences, Clemson University, Poole Agricultural Center, SC 29634-0361.
Am J Vet Res. 1994 May;55(5):722-9.
We evaluated the effectiveness of 2 dopamine antagonists as treatments for fescue toxicosis in horses. Sixteen gravid mares were assigned by breed and expected foaling date to 1 of 3 treatment groups: endophyte-infested control; 1.1 mg of domperidone/kg of body weight/d; and 3.3 mg of sulpiride/kg/d. Mares were pastured on endophyte-infected fescue and received 0.454 kg of a corn and dried molasses carrier containing the drug treatment. Treatment started 30 days prior to expected foaling date and continued until parturition. Blood samples were collected, and mammary gland scores were recorded every 5 days. Body weight and body condition scores were obtained every 28 days. Serum was analyzed for prolactin, progesterone, and estradiol-17 beta concentrations. Domperidone-treated mares had shorter (P = 0.09) gestation duration and foaled closer (P = 0.07) to their expected parturition date than did control mares. Mammary gland scores were higher (P < 0.05) for domperidone-treated mares than for control mares. By 4 and 9 days after the start of treatment, serum prolactin concentration was higher (P < 0.05) in domperidone-treated mares and sulpiride-treated mares, respectively, than in control mares. Domperidone- and sulpiride-treated mares had higher (P < 0.05) serum progesterone and lower (P < 0.01) estradiol-17 beta concentrations than did control mares. These results indicate that domperidone may offer considerable potential as a treatment for fescue toxicosis in horses.
我们评估了两种多巴胺拮抗剂对马属羊茅中毒的治疗效果。根据品种和预期产驹日期，将16匹妊娠母马分配到3个治疗组中的1组：内生真菌感染对照组；1.1毫克多潘立酮/千克体重/天；以及3.3毫克舒必利/千克/天。母马在感染内生真菌的羊茅草地上放牧，并接受0.454千克含有药物治疗的玉米和干糖蜜载体。治疗在预期产驹日期前30天开始，持续至分娩。每5天采集血样，并记录乳腺评分。每28天获取体重和体况评分。分析血清中的催乳素、孕酮和雌二醇-17β浓度。与对照母马相比，多潘立酮治疗的母马妊娠期更短（P = 0.09），产驹时间更接近（P = 0.07）预期分娩日期。多潘立酮治疗的母马乳腺评分高于对照母马（P < 0.05）。在治疗开始后的第4天和第9天，多潘立酮治疗的母马和舒必利治疗的母马血清催乳素浓度分别高于对照母马（P < 0.05）。与对照母马相比，多潘立酮和舒必利治疗的母马血清孕酮浓度更高（P < 0.05），雌二醇-17β浓度更低（P < 0.01）。这些结果表明，多潘立酮作为马属羊茅中毒的治疗药物可能具有相当大的潜力。
