Teh B H, Lin J T, Pan W H, Lin S H, Wang L Y, Lee T K, Chen C J
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Anticancer Res. 1994 May-Jun;14(3B):1389-92.
In order to estimate the seroprevalence and explore multiple risk factors associated with Helicobacter pylori infection among residents in Taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. Serum samples were tested for IgG antibodies against H. pylori by enzyme-linked immunosorbent assay using commercial kits. The overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). There was a significant geographical variation with the highest seropositive rate (63.4%) in rural area where aborigines live, and where the age-adjusted stomach cancer mortality is highest and the lowest (40.5%) in urban area where Hakkas live, and where the stomach cancer mortality is lowest. There was also an increasing seropositive rate with age from 27.1% for children younger than 10 years old to 72.3% for adults aged more than 40 years old. Age-specific seroprevalence in Taiwan is higher than that in United States, France, Finland and Australia, and lower than that in Algeria, Ivory Coast and India. No association with H. pylori seropositivity was observed for drinking water source, toilet type, family income and educational level after adjusting for age and area. A dose-response relation between H. pylori seropositivity and sibship size was found. Upon further analysis of seroprevalence for children aged 16 or younger, a positive association was observed for birth order and current number of children in family; there was also an inverse association for current number of adults in family. The early childhood transmission among siblings seems an important determinant of H. pylori seropositivity in Taiwan.
为了估计台湾居民幽门螺杆菌感染的血清流行率并探索与之相关的多种风险因素，我们对从一个大城市辖区和三个乡镇随机选取的823名受试者进行了研究。使用商用试剂盒通过酶联免疫吸附测定法检测血清样本中抗幽门螺杆菌的IgG抗体。总体血清阳性率为54.4%，无性别差异（男性为53.7%，女性为55.2%）。存在显著的地理差异，原住民居住的农村地区血清阳性率最高（63.4%），该地区年龄调整后的胃癌死亡率最高；客家人居住的城市地区血清阳性率最低（40.5%），该地区胃癌死亡率最低。血清阳性率也随年龄增长而升高，10岁以下儿童为27.1%，40岁以上成年人则为72.3%。台湾按年龄划分的血清流行率高于美国、法国、芬兰和澳大利亚，低于阿尔及利亚、科特迪瓦和印度。在调整年龄和地区后，未观察到饮用水源、厕所类型、家庭收入和教育水平与幽门螺杆菌血清阳性之间存在关联。发现幽门螺杆菌血清阳性与家庭规模之间存在剂量反应关系。在进一步分析16岁及以下儿童的血清流行率时，观察到出生顺序和家庭中现有子女数量呈正相关；家庭中现有成年人数量呈负相关。在台湾，兄弟姐妹之间的幼儿期传播似乎是幽门螺杆菌血清阳性的一个重要决定因素。
