Yu Kuan-Yi, Chuang Yu-Chuan, Huang Tien-Yu, Chou Hua-Kang, Lu Ying-Tsang, Cherng Juin-Hong, Liu Cheng-Che
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan.
Division of Gastroenterology, Tri-Service General Hospital Songshan Branch, Taipei 114, Taiwan.
Microorganisms. 2025 Mar 28;13(4):767. doi: 10.3390/microorganisms13040767.
The rapid urease test (RUT) is a reliable method for diagnosing infections in endoscopy suites; however, there is a need for tests with enhanced sensitivity and faster results. This study aimed to evaluate the diagnostic performance of the new dry detection device test compared to the gel detection device and Pronto Dry RUT in detecting infection among middle-aged and elderly Taiwanese individuals. A total of 100 participants with suspected infection undergoing upper gastroscopy were prospectively enrolled. The dry detection device demonstrated a 99% concordance rate with the Pronto Dry RUT, with seven participants testing positive for using both tests. In contrast, the gel detection device detected only six positive cases, highlighting the superior diagnostic sensitivity of the dry detection device. Additionally, the dry detection device produced significantly faster results than the gel detection device. These findings suggest that the dry detection device is a suitable and efficient RUT for diagnosing in middle-aged and elderly patients. Further studies are warranted to explore its application in broader populations and clinical settings.
快速尿素酶试验（RUT）是在内镜检查室诊断感染的可靠方法；然而，需要灵敏度更高且结果更快的检测方法。本研究旨在评估新型干式检测装置试验与凝胶检测装置和Pronto Dry RUT相比，在检测台湾中老年个体感染方面的诊断性能。前瞻性招募了100名接受上消化道内镜检查且疑似感染的参与者。干式检测装置与Pronto Dry RUT的一致性率为99%，7名参与者两种检测均呈阳性。相比之下，凝胶检测装置仅检测出6例阳性病例，凸显了干式检测装置更高的诊断灵敏度。此外，干式检测装置得出结果的速度明显快于凝胶检测装置。这些发现表明，干式检测装置是诊断中老年患者感染的合适且高效的RUT。有必要进一步研究以探索其在更广泛人群和临床环境中的应用。
