Yellowlees P M, Kaushik A V
South Australian Mental Health Service, Hillcrest Hospital, Greenacres.
Aust N Z J Psychiatry. 1994 Mar;28(1):50-7. doi: 10.3109/00048679409075845.
The objective of this clinical study was to examine the differential effects of adversity on pathology. Data obtained from a previously described consecutive series of 707 patients was re-analysed to this effect. A series of specific life events, as well as behaviours that were likely to be secondary to psychiatric disorder, were examined. High rates of life problems such as incest, sexual assault, domestic violence, suicide attempts, and alcohol, tranquilliser and substance abuse were found in the group of patients in general. There were no major differences in the prevalence of these problems in patients with major functional disorders, anxiety disorders, short-lived minor psychiatric disorders, or in "control" patients with no primary Axis I or Axis II diagnosis. Patients with personality disorders as their major psychiatric diagnosis did, however, experience higher levels of the majority of these problems. The clinical implications of the findings are discussed. It is concluded that patients who develop chronic psychiatric illnesses are probably more psychologically or biologically vulnerable than those patients who develop short-lived disorders and who do not achieve a major psychiatric diagnosis from the practising clinician.
这项临床研究的目的是检验逆境对病理学的不同影响。为此,对先前描述的707例连续病例的数据进行了重新分析。研究了一系列特定的生活事件以及可能继发于精神障碍的行为。总体而言,在患者群体中发现了诸如乱伦、性侵犯、家庭暴力、自杀未遂以及酒精、镇静剂和药物滥用等高发生率的生活问题。在患有主要功能障碍、焦虑症、短期轻度精神障碍的患者或未进行主要轴I或轴II诊断的“对照”患者中,这些问题的患病率没有重大差异。然而,以人格障碍作为主要精神诊断的患者确实经历了大多数此类问题的更高水平。讨论了研究结果的临床意义。得出的结论是,与那些患短期疾病且未被执业临床医生诊断为患有主要精神疾病的患者相比,患慢性精神疾病的患者可能在心理或生物学上更脆弱。