Ahuja S K, Gao J L, Murphy P M
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Immunol Today. 1994 Jun;15(6):281-7. doi: 10.1016/0167-5699(94)90008-6.
Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1 alpha (MIP-1 alpha)/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products, and to the Duffy antigen that mediates erythrocyte invasion by the malaria-causing parasite Plasmodium vivax. Here, Sunil Ahuja, Ji-Liang Gao and Philip Murphy suggest that, in addition to the activation of leukocytes, chemokines may be important in the function of erythrocytes and, through molecular mimicry, in microbial pathogenesis.
趋化因子是一类小的促炎肽，以其白细胞趋化活性而闻名。克隆的白细胞趋化因子受体，即A、B型白细胞介素8受体（IL-8R）以及巨噬细胞炎性蛋白1α（MIP-1α）/调节激活正常T细胞表达和分泌因子（RANTES）受体，在序列和趋化因子结合方面与两种疱疹病毒产物以及介导疟原虫（间日疟原虫）侵袭红细胞的达菲抗原相关。在这里，苏尼尔·阿胡贾、高继良和菲利普·墨菲指出，除了激活白细胞外，趋化因子可能在红细胞功能中起重要作用，并且通过分子模拟在微生物发病机制中也起重要作用。
