[结直肠癌患者健康黏膜细胞增殖的变化]
[Changes in the cellular proliferation of the healthy mucosa in patients with colorectal cancer].
作者信息
Bianchi A, Mallofre C, Soler T, Diloy R, García A, Suñol J, Barja J, Hidalgo L, Ubach M
机构信息
Servicio de Cirugía General, Consorci Sanitari de Mataró.
出版信息
Rev Esp Enferm Dig. 1994 Jun;85(6):431-4.
AIM
To analyze differences in the proliferative pattern of normal mucosa between patients with colorectal cancer and healthy subjects.
PATIENTS AND METHODS
By using flow cytometry we examined the proliferative pattern (Proliferative Index and S-Phase) in samples of normal mucosa from 34 patients operated on for colorectal cancer at our hospital and from 14 healthy subjects as a control group.
RESULTS
All examined samples were diploid. The Proliferative Index and S-Phase in the Cancer Group were significantly higher than in the Control Group (16.7 +/- 5.9 vs 11.4 +/- 4, p < 0.003, and 11.9 +/- 3.9 us 6.6 +/- 3 p < 0.0004).
CONCLUSIONS
These findings provide evidence for an altered proliferative pattern in the healthy colonic mucosa of patients with colorectal cancer.
目的
分析结直肠癌患者与健康受试者正常黏膜增殖模式的差异。
患者与方法
采用流式细胞术，我们检测了我院34例接受结直肠癌手术患者的正常黏膜样本以及作为对照组的14名健康受试者的正常黏膜样本的增殖模式（增殖指数和S期）。
结果
所有检测样本均为二倍体。癌症组的增殖指数和S期显著高于对照组（分别为16.7±5.9对11.4±4，p<0.003；以及11.9±3.9对6.6±3，p<0.0004）。
结论
这些发现为结直肠癌患者健康结肠黏膜增殖模式改变提供了证据。
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