Bianchi A, Mallofre C, Soler T, Diloy R, García A, Suñol J, Barja J, Hidalgo L, Ubach M
Servicio de Cirugía General, Consorci Sanitari de Mataró.
Rev Esp Enferm Dig. 1994 Jun;85(6):431-4.
To analyze differences in the proliferative pattern of normal mucosa between patients with colorectal cancer and healthy subjects.
By using flow cytometry we examined the proliferative pattern (Proliferative Index and S-Phase) in samples of normal mucosa from 34 patients operated on for colorectal cancer at our hospital and from 14 healthy subjects as a control group.
All examined samples were diploid. The Proliferative Index and S-Phase in the Cancer Group were significantly higher than in the Control Group (16.7 +/- 5.9 vs 11.4 +/- 4, p < 0.003, and 11.9 +/- 3.9 us 6.6 +/- 3 p < 0.0004).
These findings provide evidence for an altered proliferative pattern in the healthy colonic mucosa of patients with colorectal cancer.
分析结直肠癌患者与健康受试者正常黏膜增殖模式的差异。
采用流式细胞术，我们检测了我院34例接受结直肠癌手术患者的正常黏膜样本以及作为对照组的14名健康受试者的正常黏膜样本的增殖模式（增殖指数和S期）。
所有检测样本均为二倍体。癌症组的增殖指数和S期显著高于对照组（分别为16.7±5.9对11.4±4，p<0.003；以及11.9±3.9对6.6±3，p<0.0004）。
这些发现为结直肠癌患者健康结肠黏膜增殖模式改变提供了证据。
