Vera Sempere F J, Camañas Sanz A, Prieto Rodríguez M, Navarro Hervas M, Ramos Fernández V, Artes Martínez J
Servicio de Anatomía Patológica, Hospital Universitario La Fe.
Rev Esp Enferm Dig. 1994 Jun;85(6):440-4.
To correlate liver fine needle aspiration (FNA) diagnosis with histopathological diagnosis and clinical evolution.
Retrospective analysis of liver FNA validity, evaluating sensitivity, specificity and predictive value of the method in correlation with the clinical evolution and biopsy results.
Malignancy was diagnosed in 46 cases (20 hepatocarcinomas and 26 liver metastases), and benign lesions in 24 patients. Ten additional cases were excluded on the grounds of insufficient material or the impossibility of establishing clinico-histological correlation. There were 6 false-negatives and one false-positive. The overall accuracy of the method was 90% with a sensitivity of 88.2% and specificity of 94%. The positive and negative predictive values of the method were 97.8 and 75%, respectively.
Liver FNA is efficient in cases of suspected liver tumoration. The technique proved particularly useful in the present series in diagnosing liver metastases, often allowing the establishing of tumor origin.
将肝脏细针穿刺抽吸活检（FNA）诊断结果与组织病理学诊断结果及临床病程进行关联分析。
对肝脏FNA的有效性进行回顾性分析，评估该方法在与临床病程及活检结果关联方面的敏感性、特异性及预测价值。
46例被诊断为恶性肿瘤（20例肝细胞癌和26例肝转移瘤），24例为良性病变。另外10例因取材不足或无法建立临床-组织学关联而被排除。有6例假阴性和1例假阳性。该方法的总体准确率为90%，敏感性为88.2%，特异性为94%。该方法的阳性预测值和阴性预测值分别为97.8%和75%。
肝脏FNA对疑似肝脏肿瘤病例有效。在本研究系列中，该技术在诊断肝转移瘤方面被证明特别有用，常能确定肿瘤来源。
