Monteith G R, Chen S, Roufogalis B D
Department of Pharmacy, University of Sydney, N.S.W., Australia.
J Pharmacol Toxicol Methods. 1994 Jun;31(3):117-24. doi: 10.1016/1056-8719(94)90073-6.
Ca2+ homeostasis has been a prominent research area in the study of hypertension. There is convincing evidence that hypertension in spontaneously hypertensive rats is characterized by enhanced Ca2+ influx in various cell types. It is, however, still unclear whether hypertension is associated with reduced or enhanced Ca2+ efflux. Reduced Ca2+ efflux would augment the effects of enhanced Ca2+ influx. However, enhanced Ca2+ extrusion may occur as an adaptive process to minimize the effects of Ca2+ overload. This question remains unanswered because of inconsistent results obtained using a variety of experimental techniques. In this article we have reviewed the research findings and discuss existing and possible new techniques to assess Ca2+ efflux in hypertension, with particular attention to vascular smooth muscle. We have focused mainly on studies using the spontaneously hypertensive rat and discuss its appropriateness as a model for essential hypertension.
钙稳态一直是高血压研究中的一个重要领域。有确凿证据表明，自发性高血压大鼠的高血压特征是各种细胞类型中钙内流增强。然而，高血压与钙外流减少还是增强相关仍不清楚。钙外流减少会增强钙内流增加的效应。然而，增强的钙外排可能作为一种适应性过程发生，以尽量减少钙超载的影响。由于使用各种实验技术获得的结果不一致，这个问题仍然没有答案。在本文中，我们回顾了研究结果，并讨论了评估高血压中钙外流的现有技术和可能的新技术，特别关注血管平滑肌。我们主要关注使用自发性高血压大鼠的研究，并讨论其作为原发性高血压模型的适用性。
