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[电离辐射和琥珀酸钠作用下大鼠的存活情况及肝脏中游离NAD⁺/NADH的线粒体比率]

[Rat survival and mitochondrial ratio of free NAD+/NADH in the liver under the effect of ionizing radiation and sodium succinate].

作者信息

Kosenko E A, Kaminskiĭ Iu G

出版信息

Radiats Biol Radioecol. 1994 May-Jun;34(3):357-61.

PMID:8069368
Abstract

Free NAD+/NADH mitochondrial ratio in rat liver increased 4-12 days after whole-body animal exposure to 4 Gy but decreased to normal value at days 16-20. The administration of sodium succinate led to normalization of NAD+/NADH ratio during first few days after irradiation and increased animal survival after sublethal dose of radiation.

摘要

大鼠肝脏中游离NAD⁺/NADH线粒体比率在动物全身暴露于4 Gy辐射后4 - 12天升高,但在第16 - 20天降至正常值。给予琥珀酸钠可使辐射后最初几天的NAD⁺/NADH比率恢复正常,并提高亚致死剂量辐射后动物的存活率。

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