制霉菌素的高效液相色谱分离及其对抗真菌活性的影响。
High-performance liquid chromatographic separations of nystatin and their influence on the antifungal activity.
作者信息
Sauer B, Matusch R
机构信息
Institut für Pharmazeutische Chemie, Philipps-Universität, Marburg/Lahn, Germany.
出版信息
J Chromatogr A. 1994 Jun 24;672(1-2):247-53. doi: 10.1016/0021-9673(94)80614-4.
PMID:8069397
Abstract
Several efficient analytical HPLC methods for the separation and comparison of the nystatin complex have been developed. These separations have been extended to the preparative scale in order to gain sufficient quantities of the purified nystatin components for testing antifungal activity. For the first time we describe a new HPLC method which does not affect the antifungal activity of nystatin.
摘要
已经开发出几种用于制霉菌素复合物分离和比较的高效分析型高效液相色谱法。这些分离已扩展到制备规模，以便获得足够量的纯化制霉菌素组分用于测试抗真菌活性。我们首次描述了一种不影响制霉菌素抗真菌活性的新型高效液相色谱法。
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