Parthasarathi G, Udupa N, Umadevi P, Pillai G K
College of Pharmaceutical Sciences, K.M.C., Manipal, India.
J Drug Target. 1994;2(2):173-82. doi: 10.3109/10611869409015907.
Nonionic surfactant vesicles (niosomes) are promising drug carriers for anticancer drugs. Niosome encapsulated vincristine sulfate prepared by transmembrane pH gradient drug uptake process (remote loading method) was evaluated for toxicity and antitumour activity after administration to tumour bearing mice. The toxicity of vincristine sulfate was reduced after niosome encapsulation and anticancer activity improved, which may be due to better delivery of vincristine at the tumour site.
非离子表面活性剂囊泡（脂质体）是一种很有前景的抗癌药物载体。通过跨膜pH梯度药物摄取法（远程载入法）制备的包载硫酸长春新碱的脂质体，在给荷瘤小鼠给药后评估其毒性和抗肿瘤活性。硫酸长春新碱经脂质体包载后毒性降低，抗癌活性提高，这可能是由于长春新碱在肿瘤部位的递送效果更好。
