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Physical mapping of Xq24-25 around loci closely linked to the X-linked lymphoproliferative syndrome locus: an overlapping YAC map and linkage between DXS12, DXS42, and DXS37.

作者信息

Wang Q, Ishikawa-Brush Y, Monaco A P, Nelson D L, Caskey C T, Pauly S P, Lenoir G M, Sylla B S

机构信息

International Agency for Research on Cancer, Lyon, France.

出版信息

Eur J Hum Genet. 1993;1(1):64-71. doi: 10.1159/000472388.

DOI:10.1159/000472388
PMID:8069652
Abstract

We have localized several markers in the Xq24-25 region containing DXS12, DXS42 and DXS37 which are closely linked to the X-linked lymphoproliferative syndrome (XLP) locus. A 850-kb restriction map has been established by mapping overlapping YACs and showed that DXS12 and DXS42 are physically linked within about 50 kb. DXS37 is separated from these two loci at a maximum distance of 3,700 kb. Several new probes have been generated which will contribute to further physical mapping of this region.

摘要

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