Brenner G J, Cohen N, Moynihan J A
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642.
Cell Immunol. 1994 Sep;157(2):510-24. doi: 10.1006/cimm.1994.1246.
Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been paid to differences in immune responses between strains with different sensitivities to the virus. Here we report that immune responses (i.e., cytokine profiles, CTL activity, serum antibody, and natural killer cell activity) following footpad infection with a sublethal dose of HSV-1 do not substantially differ between the two strains. It is notable that C57BL/6 mice are also more resistant than BALB/c mice to other pathogens, including Leishmania, and this resistance is associated with a predominant TH1 response in C57BL/6 mice versus a predominant TH2 response in BALB/c mice. However, unlike several other pathogens, the increased susceptibility to HSV-1 infection of BALB/c mice, compared to C57BL/6 mice, does not appear to involve an obvious difference in the TH1 vs TH2 dominance of the immune response to this virus.
先前的研究表明，小鼠对单纯疱疹病毒1型（HSV-1）感染存在品系相关的易感性差异；C57BL/6小鼠比BALB/c小鼠对感染更具抵抗力。尽管针对HSV-1免疫反应的研究颇多，但对该病毒敏感性不同的品系之间免疫反应的差异关注相对较少。在此我们报告，用亚致死剂量的HSV-1进行足垫感染后，两种品系小鼠的免疫反应（即细胞因子谱、CTL活性、血清抗体和自然杀伤细胞活性）并无显著差异。值得注意的是，C57BL/6小鼠对包括利什曼原虫在内的其他病原体也比BALB/c小鼠更具抵抗力，且这种抵抗力与C57BL/6小鼠中占主导的TH1反应以及BALB/c小鼠中占主导的TH2反应有关。然而，与其他几种病原体不同，相较于C57BL/6小鼠，BALB/c小鼠对HSV-1感染易感性增加，这似乎并不涉及对该病毒免疫反应中TH1与TH2主导地位的明显差异。
